Respiratory disease – Communicable Diseases Research

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

[키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α Toll-like receptor 4. treated Treatment were assessed were measured
[DOI] 10.1016/j.jep.2022.115763 PMC 바로가기

3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases

Article

Published on 2022-12-012022-11-15
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제,

[키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while
[DOI] 10.1080/22221751.2022.2117101 PMC 바로가기

Potential intestinal infection and faecal-oral transmission of human coronaviruses

Article

Published on 2022-11-012022-11-15
Journal: Reviews in Medical Virology
[Category] COVID19(2023년), SARS, 치료기술,

Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of Iran

Article

Published on 2022-11-012022-11-15
Journal: Clinica chimica acta; international journal of cli
[Category] 진단,

[키워드] ACE1 acute respiratory syndrome affecting Angiotensin-converting enzyme Angiotensin-converting enzyme 1 Care case-control study caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 susceptibility death disease enzyme Ethnic groups Factor Frequency Genetic Genotype genotyped Health healthy controls I/D polymorphism Infection Iran KCNIP4 material outcome pandemic pathogen PCR polymorphism Polymorphisms populations Potassium Prognostic factor Protein Region Research Respiratory disease severe acute respiratory syndrome coronavirus 2 severity statistically significant supported survival Variation Voltage-gated potassium (Kv) channel-interacting protein 4.
[DOI] 10.1016/j.cca.2022.09.006 PMC 바로가기

Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDS

Article

Published on 2022-10-172022-11-15
Journal: PLoS ONE
[Category] 치료제,

[키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease
[DOI] 10.1371/journal.pone.0275181 PMC 바로가기

Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 study

Article

Published on 2022-10-102022-11-15
Journal: Respiratory Research
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2. severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed
[DOI] 10.1186/s12931-022-02190-8 PMC 바로가기

Estimation of biochemical factors affecting survival in intensive care COVID-19 patients undergoing chest CT scoring: A retrospective cross-sectional study

Article

Published on 2022-10-072022-11-16
Journal: Medicine
[Category] 변종,

[키워드] 95% CI Affect affecting age APACHE II APACHE II score approval biochemical Blood urea nitrogen changed Chest computed tomography Chest CT chest CT scan conducted Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Data analysis determine died estimation ethics committee Factor faculty females Follow-up greater Health ICU intensive care Invasive mechanical ventilation laboratory parameter males marker Mortality mortality rate no significant difference nonsurvivor nonsurvivors pandemic Patient PCR PCR test polymerase chain positive Prognosis ranged Respiratory disease Retrospective cross-sectional study significantly SPSS survival survivor symptomatic patient the mean the patient the WHO Transmission university variant was used were recorded widespread window Wuhan
[DOI] 10.1097/MD.0000000000030407 PMC 바로가기

COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment management

Review article

Published on 2022-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome addition aggravate Asymptomatic caused Characteristics chronic liver disease cirrhosis clinical clinical manifestation Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient Critical death disease dysfunction Epidemic extrapulmonary organs Factors hepatic function Hepatocellular carcinoma hypoxia immune increased risk infection with SARS-CoV-2 inflammatory factor storms Injury liver Liver damage Liver disease liver enzyme Liver function Liver injury liver transplant Liver transplantation management mechanism nonalcoholic fatty liver pathophysiological mechanism Patient patients prevalent public health reperfusion Respiratory disease risk SARS-CoV-2 severe disease Stress Treatment Vaccine
[DOI] 10.1016/j.biopha.2022.113568 [Article Type] Review article

Neuroinflammation and COVID-19

Review article

Published on 2022-10-012022-10-05
Journal: Current Opinion in Neurobiology
[Category] COVID19(2023년), SARS, 바이오마커, 치료기술,

COVID-19 related vascular complications in a pediatric patient: A case report

Case report

Published on 2022-10-012022-10-05
Journal: Radiology Case Reports
[Category] 진단, 치료기술,

[키워드] “cytokine storm” Ageusia Anosmia Atypical Case report caused classical Complication concerning COVID-19 COVID-19 complications COVID-19 vasculitis dry cough Dyspnea elevated endothelial Fever global pandemic healthy include increasingly Infection Inflammatory marker inflammatory mediator inquiry Invasion Laboratory test large vessel male Manifestations Neurological complication NEURORADIOLOGY Novel coronavirus infection pathophysiology pediatric Pediatric neuroradiology positive presenting radiological Rash Respiratory disease SARS-COV-2 infection Seizure shown subsequent Testing the disease the SARS-CoV-2 virus Vascular Vasculitis while widespread
[DOI] 10.1016/j.radcr.2022.07.051 [Article Type] Case report